Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Rodriguez N
PROVIDER: S-EPMC4392241 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20150220 15
Regulation of intracellular ion homeostasis is essential for eukaryotic cell physiology. An example is provided by loss of ATP2C1 function, which leads to skin ulceration, improper keratinocyte adhesion, and cancer formation in Hailey-Hailey patients. The yeast ATP2C1 orthologue PMR1 codes for a Mn(2+)/Ca(2+) transporter that is crucial for cis-Golgi manganese supply. Here, we present evidence that calcium overcomes the lack of Pmr1 through vesicle trafficking-stimulated manganese delivery and r ...[more]