Ontology highlight
ABSTRACT:
SUBMITTER: Murry JP
PROVIDER: S-EPMC4392775 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Virology 20141011
Long-lived pools of latently infected cells are a significant barrier to the development of a cure for HIV-1 infection. A better understanding of the mechanisms of reactivation from latency is needed to facilitate the development of novel therapies that address this problem. Here we show that chemical inhibitors of the sulfonation pathway prevent virus reactivation, both in latently infected J-Lat and U1 cell lines and in a primary human CD4+ T cell model of latency. In each of these models, sul ...[more]