Ontology highlight
ABSTRACT:
SUBMITTER: Pan XY
PROVIDER: S-EPMC4870680 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Scientific reports 20160518
HSF1, a conserved heat shock factor, has emerged as a key regulator of mammalian transcription in response to cellular metabolic status and stress. To our knowledge, it is not known whether HSF1 regulates viral transcription, particularly HIV-1 and its latent form. Here we reveal that HSF1 extensively participates in HIV transcription and is critical for HIV latent reactivation. Mode of action studies demonstrated that HSF1 binds to the HIV 5'-LTR to reactivate viral transcription and recruits a ...[more]