Ontology highlight
ABSTRACT:
SUBMITTER: Ma W
PROVIDER: S-EPMC4393844 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20150219 8
Ring-shaped, hexameric ATPase motors fulfill key functions in cellular processes, such as genome replication, transcription, or protein degradation, by translocating a long substrate through their central pore powered by ATP hydrolysis. Despite intense research efforts, the atomic-level mechanism transmitting chemical energy from hydrolysis into mechanical force that translocates the substrate is still unclear. Here we employ all-atom molecular dynamics simulations combined with advanced path sa ...[more]