Ontology highlight
ABSTRACT:
SUBMITTER: Silva DA
PROVIDER: S-EPMC4040580 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Silva Daniel-Adriano DA Weiss Dahlia R DR Pardo Avila Fátima F Da Lin-Tai LT Levitt Michael M Wang Dong D Huang Xuhui X
Proceedings of the National Academy of Sciences of the United States of America 20140421 21
Transcription is a central step in gene expression, in which the DNA template is processively read by RNA polymerase II (Pol II), synthesizing a complementary messenger RNA transcript. At each cycle, Pol II moves exactly one register along the DNA, a process known as translocation. Although X-ray crystal structures have greatly enhanced our understanding of the transcription process, the underlying molecular mechanisms of translocation remain unclear. Here we use sophisticated simulation techniq ...[more]