Ontology highlight
ABSTRACT:
SUBMITTER: Williams CH
PROVIDER: S-EPMC4394042 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Williams Charles H CH Hempel Jonathan E JE Hao Jijun J Frist Audrey Y AY Williams Michelle M MM Fleming Jonathan T JT Sulikowski Gary A GA Cooper Michael K MK Chiang Chin C Hong Charles C CC
Cell reports 20150326 1
Hedgehog (Hh) signaling plays an integral role in vertebrate development, and its dysregulation has been accepted widely as a driver of numerous malignancies. While a variety of small molecules target Smoothened (Smo) as a strategy for Hh inhibition, Smo gain-of-function mutations have limited their clinical implementation. Modulation of targets downstream of Smo could define a paradigm for treatment of Hh-dependent cancers. Here, we describe eggmanone, a small molecule identified from a chemica ...[more]