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ABSTRACT:
SUBMITTER: Puljula E
PROVIDER: S-EPMC4394349 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Puljula Elina E Turhanen Petri P Vepsäläinen Jouko J Monteil Maelle M Lecouvey Marc M Weisell Janne J
ACS medicinal chemistry letters 20150221 4
Eighteen different bisphosphonates, including four clinically used bisphosphonate acids and their phosphoesters, were studied to evaluate how the bisphosphonate structure affects binding to bone. Bisphosphonates with weak bone affinity, such as clodronate, could not bind to hydroxyapatite after the addition of one ester group. Medronate retained its ability to bind after the addition of one ester group, and hydroxy-bisphosphonates could bind even after the addition of two ester groups. Thus, sev ...[more]