Ontology highlight
ABSTRACT:
SUBMITTER: Tsukamoto H
PROVIDER: S-EPMC4396369 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Tsukamoto Hirotake H Senju Satoru S Matsumura Keiko K Swain Susan L SL Nishimura Yasuharu Y
Nature communications 20150407
Decline in immune function and inflammation concomitantly develop with ageing. Here we focus on the impact of this inflammatory environment on T cells, and demonstrate that in contrast to successful tumour elimination in young mice, replenishment of tumour-specific CD4(+) T cells fails to induce tumour regression in aged hosts. The impaired antitumour effect of CD4(+) T cells with their defective Th1 differentiation in an aged environment is restored by interleukin (IL)-6 blockade or IL-6 defici ...[more]