Influence of host resistance on viral adaptation: hepatitis C virus as a case study.
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ABSTRACT:
SUBMITTER: Plauzolles A
PROVIDER: S-EPMC4396509 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Influence of host resistance on viral adaptation: hepatitis C virus as a case study.
Plauzolles Anne A Lucas Michaela M Gaudieri Silvana S
Infection and drug resistance 20150407
Genetic and cellular studies have shown that the host's innate and adaptive immune responses are an important correlate of viral infection outcome. The features of the host's immune response (host resistance) reflect the coevolution between hosts and pathogens that has occurred over millennia, and that has also resulted in a number of strategies developed by viruses to improve fitness and survival within the host (viral adaptation). In this review, we discuss viral adaptation to host immune pres ...[more]
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