Ontology highlight
ABSTRACT:
SUBMITTER: Glukhova A
PROVIDER: S-EPMC4397983 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Glukhova Alisa A Hinkovska-Galcheva Vania V Kelly Robert R Abe Akira A Shayman James A JA Tesmer John J G JJ
Nature communications 20150302
Lysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT) belong to a structurally uncharacterized family of key lipid-metabolizing enzymes responsible for lung surfactant catabolism and for reverse cholesterol transport, respectively. Whereas LPLA2 is predicted to underlie the development of drug-induced phospholipidosis, somatic mutations in LCAT cause fish eye disease and familial LCAT deficiency. Here we describe several high-resolution crystal structures of human LP ...[more]