Ontology highlight
ABSTRACT:
SUBMITTER: Manthei KA
PROVIDER: S-EPMC6962161 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Manthei Kelly A KA Patra Dhabaleswar D Wilson Christopher J CJ Fawaz Maria V MV Piersimoni Lolita L Shenkar Jenny Capua JC Yuan Wenmin W Andrews Philip C PC Engen John R JR Schwendeman Anna A Ohi Melanie D MD Tesmer John J G JJG
Communications biology 20200115 1
Lecithin:cholesterol acyltransferase (LCAT) catalyzes a critical step of reverse cholesterol transport by esterifying cholesterol in high density lipoprotein (HDL) particles. LCAT is activated by apolipoprotein A-I (ApoA-I), which forms a double belt around HDL, however the manner in which LCAT engages its lipidic substrates and ApoA-I in HDL is poorly understood. Here, we used negative stain electron microscopy, crosslinking, and hydrogen-deuterium exchange studies to refine the molecular detai ...[more]