Ontology highlight
ABSTRACT:
SUBMITTER: Shaw J
PROVIDER: S-EPMC4398321 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Shaw Joseph J Fishwick Colin W G CW Harris Mark M
Antiviral research 20150220
Hepatitis C virus (HCV) non-structural 2 (NS2) encodes an essential protease activity responsible for processing at the NS2-NS3 junction which represents an attractive antiviral target. Attempts to inhibit the NS2 autoprotease with mechanism-based protease inhibitors and substrate peptides have had limited success. We report a series of epoxide-containing small molecules capable of blocking NS2-NS3 proteolysis in vitro and demonstrate the potential for selectivity towards the NS2 autoprotease. A ...[more]