Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen.
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ABSTRACT:
SUBMITTER: Peng LF
PROVIDER: S-EPMC2043288 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Publications
Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen.
Peng Lee F LF Kim Sun Suk SS Matchacheep Sirinya S Lei Xiaoguang X Su Shun S Lin Wenyu W Runguphan Weerawat W Choe Won-Hyeok WH Sakamoto Naoya N Ikeda Masanori M Kato Nobuyuki N Beeler Aaron B AB Porco John A JA Schreiber Stuart L SL Chung Raymond T RT
Antimicrobial agents and chemotherapy 20070806 10
Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 microM). We then synthesized an analog of these compounds with optimized activity. ...[more]
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