Ontology highlight
ABSTRACT:
SUBMITTER: Tian H
PROVIDER: S-EPMC4398612 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Tian Hui H Lu Jui-Yun JY Shao Chunli C Huffman Kenneth E KE Carstens Ryan M RM Larsen Jill E JE Girard Luc L Liu Hui H Rodriguez-Canales Jaime J Frenkel Eugene P EP Wistuba Ignacio I II Minna John D JD Hofmann Sandra L SL
Molecular cancer research : MCR 20150108 4
<h4>Unlabelled</h4>Protein S-palmitoylation is a widespread and dynamic posttranslational modification that regulates protein-membrane interactions, protein-protein interactions, and protein stability. A large family of palmitoyl acyl transferases, termed the DHHC family due to the presence of a common catalytic motif, catalyzes S-palmitoylation; the role of these enzymes in cancer is largely unexplored. In this study, an RNAi-based screen targeting all 23 members of the DHHC family was conducte ...[more]