Isoprenoid metabolism in apicomplexan parasites.
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ABSTRACT:
SUBMITTER: Imlay L
PROVIDER: S-EPMC4399553 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Isoprenoid metabolism in apicomplexan parasites.
Current clinical microbiology reports 20141201 3-4
Apicomplexan parasites include some of the most prevalent and deadly human pathogens. Novel antiparasitic drugs are urgently needed. Synthesis and metabolism of isoprenoids may present multiple targets for therapeutic intervention. The apicoplast-localized methylerythritol phosphate (MEP) pathway for isoprenoid precursor biosynthesis is distinct from the mevalonate (MVA) pathway used by the mammalian host, and this pathway is apparently essential in most Apicomplexa. In this review, we discuss t ...[more]
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