Ontology highlight
ABSTRACT:
SUBMITTER: McPhillie MJ
PROVIDER: S-EPMC7311950 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in cellular and infection microbiology 20200609
Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, a tetrahydroquinolone, with increased sp3-character to improve parasite selectivity. Relative to other cytochrome <i>b</i> inhibitors, JAG21 has improved solubility and ADMET properties, without need for pro-drug. JAG21 significantly reduces <i>Toxoplasma gondii</i> tachyzoites and encysted bradyzoites <i>in ...[more]