Ontology highlight
ABSTRACT:
SUBMITTER: Tom JK
PROVIDER: S-EPMC4399865 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Tom Janine K JK Mancini Rock J RJ Esser-Kahn Aaron P AP
Chemical communications (Cambridge, England) 20131001 83
We present a primary example of a cell surface modified with a synergistic combination of agonists to tune immune stimulation. A model cell line, Lewis Lung Carcinoma, was covalently modified with CpG-oligonucleotides and lipoteichoic acid, both Toll-like receptor (TLR) agonists. The immune-stimulating constructs provided greater stimulation of NF-κB in a model cell line and bone marrow-derived dendritic cells than the components unconjugated in solution. ...[more]