Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis.
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ABSTRACT:
SUBMITTER: Westerberg PA
PROVIDER: S-EPMC4400509 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
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Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis.
Westerberg Per-Anton PA Linde Torbjörn T Vanderschueren Dirk D Billen Jaak J Jans Ivo I Ljunggren Östen Ö
Clinical kidney journal 20120329 3
In oncogenic osteomalacia (OOM), fibroblast growth factor 23 (FGF23) induces renal phosphate wasting and inhibits the appropriate increase of calcitriol. A patient suffering from OOM is described. Serum calcium, phosphate, biointact parathyroid hormone and intact FGF23 as well as the calcitriol and 24,25-vitamin D levels were measured before and after tumour removal. The clinical approach to a patient with hypophosphataemia is discussed and the changes in mineral metabolism after removal of a FG ...[more]
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