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First human case of fatal Halicephalobus gingivalis meningoencephalitis in Australia.

ABSTRACT: Halicephalobus gingivalis (previously Micronema deletrix) is a free-living nematode known to cause opportunistic infections, mainly in horses. Human infections are very rare, but all cases described to date involved fatal meningoencephalitis. Here we report the first case of H. gingivalis infection in an Australian human patient, confirmed by nematode morphology and sequencing of ribosomal DNA. The implications of this case are discussed, particularly, the need to evaluate real-time PCR as a diagnostic tool.

SUBMITTER: Lim CK

PROVIDER: S-EPMC4400780 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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First human case of fatal Halicephalobus gingivalis meningoencephalitis in Australia.

Lim Chuan Kok CK Crawford April A Moore Casey V CV Gasser Robin B RB Nelson Renjy R Koehler Anson V AV Bradbury Richard S RS Speare Rick R Dhatrak Deepak D Weldhagen Gerhard F GF

Journal of clinical microbiology 20150218 5

Halicephalobus gingivalis (previously Micronema deletrix) is a free-living nematode known to cause opportunistic infections, mainly in horses. Human infections are very rare, but all cases described to date involved fatal meningoencephalitis. Here we report the first case of H. gingivalis infection in an Australian human patient, confirmed by nematode morphology and sequencing of ribosomal DNA. The implications of this case are discussed, particularly, the need to evaluate real-time PCR as a dia ...[more]

PMID: 25694532

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