Ontology highlight
ABSTRACT:
SUBMITTER: Menck K
PROVIDER: S-EPMC4401212 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Menck Kerstin K Scharf Christian C Bleckmann Annalen A Dyck Lydia L Rost Ulrike U Wenzel Dirk D Dhople Vishnu M VM Siam Laila L Pukrop Tobias T Binder Claudia C Klemm Florian F
Journal of molecular cell biology 20141211 2
Tumor cells secrete not only a variety of soluble factors, but also extracellular vesicles that are known to support the establishment of a favorable tumor niche by influencing the surrounding stroma cells. Here we show that tumor-derived microvesicles (T-MV) also directly influence the tumor cells by enhancing their invasion in a both autologous and heterologous manner. Neither the respective vesicle-free supernatant nor MV from benign mammary cells mediate invasion. Uptake of T-MV is essential ...[more]