Ontology highlight
ABSTRACT:
SUBMITTER: Schumak B
PROVIDER: S-EPMC4401438 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Schumak Beatrix B Klocke Katrin K Kuepper Janina M JM Biswas Aindrila A Djie-Maletz Andrea A Limmer Andreas A van Rooijen Nico N Mack Matthias M Hoerauf Achim A Dunay Ildiko Rita IR
PloS one 20150417 4
Plasmodium berghei ANKA (PbA) infection of C57BL/6 mice leads to experimental cerebral malaria (ECM) that is commonly associated with serious T cell mediated damage. In other parasitic infection models, inflammatory monocytes have been shown to regulate Th1 responses but their role in ECM remains poorly defined, whereas neutrophils are reported to contribute to ECM immune pathology. Making use of the recent development of specific monoclonal antibodies (mAb), we depleted in vivo Ly6C(hi) inflamm ...[more]