Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen KD
PROVIDER: S-EPMC3836670 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Nguyen Khoa D KD Fentress Sarah J SJ Qiu Yifu Y Yun Karen K Cox Jeffery S JS Chawla Ajay A
Science (New York, N.Y.) 20130822 6153
Circadian clocks have evolved to regulate physiologic and behavioral rhythms in anticipation of changes in the environment. Although the molecular clock is present in innate immune cells, its role in monocyte homeostasis remains unknown. Here, we report that Ly6C(hi) inflammatory monocytes exhibit diurnal variation, which controls their trafficking to sites of inflammation. This cyclic pattern of trafficking confers protection against Listeria monocytogenes and is regulated by the repressive act ...[more]