Genetic polymorphism in extracellular regulators of Wnt signaling pathway.
Ontology highlight
ABSTRACT:
SUBMITTER: Sharma G
PROVIDER: S-EPMC4402192 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Genetic polymorphism in extracellular regulators of Wnt signaling pathway.
Sharma Garima G Sharma Ashish Ranjan AR Seo Eun-Min EM Nam Ju-Suk JS
BioMed research international 20150405
The Wnt signaling pathway is mediated by a family of secreted glycoproteins through canonical and noncanonical mechanism. The signaling pathways are regulated by various modulators, which are classified into two classes on the basis of their interaction with either Wnt or its receptors. Secreted frizzled-related proteins (sFRPs) are the member of class that binds to Wnt protein and antagonizes Wnt signaling pathway. The other class consists of Dickkopf (DKK) proteins family that binds to Wnt rec ...[more]
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