Dataset Information

Prognostic value of histological type in stage IV ovarian carcinoma: a retrospective analysis of 223 patients.

ABSTRACT:

Background

Patients with FIGO stage IV epithelial ovarian carcinoma have a poor but non-uniform prognosis. This study aimed to compare the survival of patients with serous or endometrioid tumours (S/E) and clear cell or mucinous tumours (non-S/E).

Methods

Data for 223 patients who underwent surgery between 1987 and 2010 and were diagnosed by centralized pathology review and were retrospectively analysed. The patients included 169 with S/E tumours and 54 with non-S/E tumours.

Results

The median overall survivals (OSs) of the S/E and non-S/E groups were 3.1 and 0.9 years, respectively (P<0.001). Six patients (2.7%), all with non-S/E tumours, died within 6 weeks after the initial surgery. Multivariate OS analysis revealed that performance status, residual tumor, metastatic sites, no debulking surgery, and non-S/E tumours were independent poor prognostic factors. For patients with non-S/E tumours, prognosis was more favourable for single-organ metastasis, except for liver or distant lymph nodes, no residual tumor, and resection of metastasis (median OS: 4.1, 4.6, and 2.6 years, respectively).

Conclusions

In stage IV ovarian carcinoma, non-S/E tumours are associated with a significantly poorer prognosis and higher rates of early mortality compared to S/E tumours. Therefore, careful management and development of new strategies are required.

SUBMITTER: Mizuno M

PROVIDER: S-EPMC4402461 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Prognostic value of histological type in stage IV ovarian carcinoma: a retrospective analysis of 223 patients.

Mizuno M M Kajiyama H H Shibata K K Mizuno K K Kawai M M Nagasaka T T Kikkawa F F

British journal of cancer 20150324 8

<h4>Background</h4>Patients with FIGO stage IV epithelial ovarian carcinoma have a poor but non-uniform prognosis. This study aimed to compare the survival of patients with serous or endometrioid tumours (S/E) and clear cell or mucinous tumours (non-S/E).<h4>Methods</h4>Data for 223 patients who underwent surgery between 1987 and 2010 and were diagnosed by centralized pathology review and were retrospectively analysed. The patients included 169 with S/E tumours and 54 with non-S/E tumours.<h4>Re ...[more]

PMID: 25867257

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Dataset Information

Prognostic value of histological type in stage IV ovarian carcinoma: a retrospective analysis of 223 patients.

Background

Methods

Results

Conclusions

Publications

Prognostic value of histological type in stage IV ovarian carcinoma: a retrospective analysis of 223 patients.

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