Ontology highlight
ABSTRACT:
SUBMITTER: Kang HA
PROVIDER: S-EPMC4402518 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Kang Hyun-Ah HA Shin Ho-Chul HC Kalantzi Alexandra-Styliani AS Toseland Christopher P CP Kim Hyun-Min HM Gruber Stephan S Peraro Matteo Dal MD Oh Byung-Ha BH
Nucleic acids research 20150303 7
In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism. Here, the crystal structure of Hop2-Mnd1 reveals that it forms a curved rod-like structure consisting of three leucine zippers and two kinked junctions. One end of the rod is linked to two juxtaposed winged-helix domains, and the other end is capped by extra α-helices to form a helical bundle-like struct ...[more]