Dataset Information

The association between the rs11549465 polymorphism in the hif-1? gene and cancer risk: a meta-analysis.

ABSTRACT: PURPOSE:The associations between hypoxia-inducible factor-1 alpha (HIF-1alpha) and clinicopathological characteristics of cancers have been evaluated in various studies, with the conflicting results. The common rs11549465 (1772C/T) genetic polymorphism has been reported to be functional and may contribute to genetic susceptibility to cancers. However, the association between rs11549465 (1772C/T) and cancer risk remains inconclusive. METHODS:To better understand the role of rs11549465 (1772C/T) polymorphism in global cancer, we conducted this comprehensive meta-analysis encompassing 7807 cases and 8633 controls. RESULTS:Overall, the rs11549465 (1772C/T) genetic polymorphism was associated with higher cancer risk, especially exists in Asians. In the stratified analysis, significant associations were found between the HIF-1 rs11549465 polymorphism and gynecologic cancer among Caucasian population. We observed that the TT genotype might modulate gynecologic cancer (OR=9.92 [2.15-45.66]) risk comparing with the CC genotype. Moreover, a significantly increased lung and breast cancer risk was found among Asian population comparing with Caucasian population. When stratified by study design, significantly elevated susceptibility to cancer was found among hospital -based studies. CONCLUSIONS:Our meta-analysis suggested that the HIF-1 rs11549465 (1772C/T) genetic polymorphism is significantly associated with higher risk among Asian population and lower risk among Caucasian population in breast and lung cancer, and this SNP was significantly associated with the gynecologic cancer among Caucasian population. The effect of the rs11549465 polymorphism on cancer especially exists in Asians.

SUBMITTER: Li Y

PROVIDER: S-EPMC4402731 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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The association between the rs11549465 polymorphism in the hif-1α gene and cancer risk: a meta-analysis.

Li Yujie Y Li Chunyan C Shi Hui H Lou Lieming L Liu Pengcheng P

International journal of clinical and experimental medicine 20150215 2

<h4>Purpose</h4>The associations between hypoxia-inducible factor-1 alpha (HIF-1alpha) and clinicopathological characteristics of cancers have been evaluated in various studies, with the conflicting results. The common rs11549465 (1772C/T) genetic polymorphism has been reported to be functional and may contribute to genetic susceptibility to cancers. However, the association between rs11549465 (1772C/T) and cancer risk remains inconclusive.<h4>Methods</h4>To better understand the role of rs11549 ...[more]

PMID: 25932084

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Project description:BackgroundPhosphatase and tensin homolog (PTEN) is a well established tumor suppressor gene. Recently, increasing studies investigated the association between PTEN IVS4 polymorphism (rs3830675) and risk of various types of cancer. However, the results from the individual studies were controversial. The aim of this meta-analysis was to elucidate whether PTEN IVS4 polymorphism was associated with cancer risk.MethodsDatabases including PubMed, Web of knowledge and Chinese National Knowledge Infrastructure (CNKI) were systematically searched to identify potentially eligible literatures. Odds ratios (OR) and their 95% confidence interval (CI) were used to assess the strength of association between PTEN IVS4 polymorphism and cancer risk.ResultsA total of seven case-control studies were finally included in this meta-analysis. The pooled analysis suggested that individuals with PTEN IVS4 (-/-) genotype were significantly associated with increased risk of cancer (OR = 1.45, 95% CI = 1.19-1.76, P<0.001) and subgroup of digestive tract cancer (OR = 1.67, 95% CI = 1.28-2.18, P<0.001) compared with (+/+) genotype. The allele analysis revealed that (-) allele was significantly associated with increased risk of cancer (OR = 1.30, 95% CI = 1.12-1.50, P = 0.001) and subgroup of digestive tract cancer (OR = 1.42, 95% CI = 1.16-1.74, P = 0.001) compared with (+) allele. No significant association was observed between PTEN IVS4 (+/-) genotype and risk of cancer.ConclusionPTEN IVS4 (-/-) genotype was significantly associated with increased risk of cancer especially for digestive tract cancer compared with (+/+) genotype. The (-) allele of PTEN IVS4 (rs3830675) polymorphism was significantly associated with increased risk of cancer especially for digestive tract cancer compared with (+) allele. The recessive effect model and dominant effect model also demonstrated significant association between PTEN IVS4 (rs3830675) polymorphism and increased cancer risk especially for digestive tract cancer. Further large-scale and well-designed studies regarding different ethnicities are still required to confirm the results of our meta-analysis.

Dataset Information

The association between the rs11549465 polymorphism in the hif-1? gene and cancer risk: a meta-analysis.

Publications

The association between the rs11549465 polymorphism in the hif-1α gene and cancer risk: a meta-analysis.

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