Ontology highlight
ABSTRACT:
SUBMITTER: Whidbey C
PROVIDER: S-EPMC4403049 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Whidbey Christopher C Vornhagen Jay J Gendrin Claire C Boldenow Erica E Samson Jenny Mae JM Doering Kenji K Ngo Lisa L Ezekwe Ejiofor A D EA Gundlach Jens H JH Elovitz Michal A MA Liggitt Denny D Duncan Joseph A JA Adams Waldorf Kristina M KM Rajagopal Lakshmi L
EMBO molecular medicine 20150401 4
Group B streptococci (GBS) are Gram-positive bacteria that cause infections in utero and in newborns. We recently showed that the GBS pigment is hemolytic and increased pigment production promotes bacterial penetration of human placenta. However, mechanisms utilized by the hemolytic pigment to induce host cell lysis and the consequence on fetal injury are not known. Here, we show that the GBS pigment induces membrane permeability in artificial lipid bilayers and host cells. Membrane defects indu ...[more]