Ontology highlight
ABSTRACT:
SUBMITTER: Lecoeur H
PROVIDER: S-EPMC3317353 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Lecoeur H H Borgne-Sanchez A A Chaloin O O El-Khoury R R Brabant M M Langonné A A Porceddu M M Brière J-J JJ Buron N N Rebouillat D D Péchoux C C Deniaud A A Brenner C C Briand J-P JP Muller S S Rustin P P Jacotot E E
Cell death & disease 20120315
The Trans-activator protein (Tat) of human immunodeficiency virus (HIV) is a pleiotropic protein involved in different aspects of AIDS pathogenesis. As a number of viral proteins Tat is suspected to disturb mitochondrial function. We prepared pure synthetic full-length Tat by native chemical ligation (NCL), and Tat peptides, to evaluate their direct effects on isolated mitochondria. Submicromolar doses of synthetic Tat cause a rapid dissipation of the mitochondrial transmembrane potential (ΔΨ(m) ...[more]