Ontology highlight
ABSTRACT:
SUBMITTER: Sharon D
PROVIDER: S-EPMC4403978 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Sharon David D Chen Min M Zhang Guangzhi G Girgis Safwat S Sis Banu B Graham Don D McDougall Chelsea C Wasilenko Shawn T ST Montano-Loza Aldo A Mason Andrew L AL
Liver international : official journal of the International Association for the Study of the Liver 20141031 4
<h4>Background & aims</h4>The NOD.c3c4 mouse model develops autoimmune biliary disease characterized by spontaneous granulomatous cholangitis, antimitochondrial antibodies and liver failure. This model for primary biliary cirrhosis (PBC) has evidence of biliary infection with mouse mammary tumour virus (MMTV), suggesting that the virus may have a role in cholangitis development and progression of liver disease in this mouse model. We tested the hypothesis that MMTV infection is associated with c ...[more]