RNA-targeted Therapeutics for ALS.
Ontology highlight
ABSTRACT:
SUBMITTER: Reddy LV
PROVIDER: S-EPMC4404448 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
RNA-targeted Therapeutics for ALS.
Reddy Linga V LV Miller Timothy M TM
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20150401 2
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease leading to cell death of predominantly motor neurons. Despite extensive research in this disease, finding a way to slow the progress of the disease has been challenging. RNA-targeted therapeutic approaches, including small interfering RNA and antisense oligonucleotides are being developed for genetic forms of ALS. ALS provides an unique opportunity for the use of RNA inhibition strategies given a well-defined animal model, extens ...[more]
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