Harnessing MerTK agonism for targeted therapeutics.
Ontology highlight
ABSTRACT: Phagocytosis plays important roles both in homeostasis and under pathological conditions. Fcγ receptor-mediated phagocytosis has been exploited as an integral mechanism for antibody-based therapies. Unlike Fcγ receptor-mediated phagocytosis, MerTK-mediated phagocytic clearance is immunologically silent. Here, we describe a bispecific antibody approach to harness MerTK for targeted clearance without inducing proinflammatory cytokine release associated with Fcγ receptor engagement. We generated bispecific antibodies targeting live B cells or amyloid beta aggregates to demonstrate the feasibility and versatility of this new approach.
SUBMITTER: Kedage V
PROVIDER: S-EPMC6927767 | biostudies-literature |
REPOSITORIES: biostudies-literature
ACCESS DATA