Ontology highlight
ABSTRACT:
SUBMITTER: Finnegan DF
PROVIDER: S-EPMC4405029 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Finnegan David F DF Shelnut Erin L EL Nikas Spyros P SP Chiang Nan N Serhan Charles N CN Makriyannis Alexandros A
Bioorganic & medicinal chemistry letters 20150204 6
We report the design and synthesis of novel prostaglandin-ethanolamide (PGE2-EA) analogs containing head and tail group modifications to aid in the characterization of a putative prostamide receptor(s). Our synthetic approach utilizes Horner-Wadsworth-Emmons and Wittig reactions to construct the head and the tail moieties of the key PGE2 precursor, which leads to the final products through a peptide coupling, Swern oxidation and HF/pyridine assisted desilylation. The synthesized analogs were sho ...[more]