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Ruthenium-catalyzed C-C coupling of fluorinated alcohols with allenes: dehydrogenation at the energetic limit of ?-hydride elimination.

ABSTRACT: Ruthenium(II) complexes catalyze the C?C coupling of 1,1-disubstituted allenes and fluorinated alcohols to form homoallylic alcohols bearing all-carbon quaternary centers with good to complete levels of diastereoselectivity. Whereas fluorinated alcohols are relatively abundant and tractable, the corresponding aldehydes are often not commercially available because of their instability.

SUBMITTER: Sam B 

PROVIDER: S-EPMC4405479 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Ruthenium-catalyzed C-C coupling of fluorinated alcohols with allenes: dehydrogenation at the energetic limit of β-hydride elimination.

Sam Brannon B   Luong Tom T   Krische Michael J MJ  

Angewandte Chemie (International ed. in English) 20150310 18

Ruthenium(II) complexes catalyze the CC coupling of 1,1-disubstituted allenes and fluorinated alcohols to form homoallylic alcohols bearing all-carbon quaternary centers with good to complete levels of diastereoselectivity. Whereas fluorinated alcohols are relatively abundant and tractable, the corresponding aldehydes are often not commercially available because of their instability. ...[more]

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