Alternative splicing of SMPD1 in human sepsis.
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ABSTRACT:
SUBMITTER: Kramer M
PROVIDER: S-EPMC4405572 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Alternative splicing of SMPD1 in human sepsis.
Kramer Marcel M Quickert Stefanie S Sponholz Christoph C Menzel Uwe U Huse Klaus K Platzer Matthias M Bauer Michael M Claus Ralf A RA
PloS one 20150421 4
Acid sphingomyelinase (ASM or sphingomyelin phosphodiesterase, SMPD) activity engages a critical role for regulation of immune response and development of organ failure in critically ill patients. Beside genetic variation in the human gene encoding ASM (SMPD1), alternative splicing of the mRNA is involved in regulation of enzymatic activity. Here we show that the patterns of alternatively spliced SMPD1 transcripts are significantly different in patients with systemic inflammatory response syndro ...[more]
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