Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC5554779 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Liu Yansheng Y Gonzàlez-Porta Mar M Santos Sergio S Brazma Alvis A Marioni John C JC Aebersold Ruedi R Venkitaraman Ashok R AR Wickramasinghe Vihandha O VO
Cell reports 20170801 5
Alternative splicing is a critical determinant of genome complexity and, by implication, is assumed to engender proteomic diversity. This notion has not been experimentally tested in a targeted, quantitative manner. Here, we have developed an integrative approach to ask whether perturbations in mRNA splicing patterns alter the composition of the proteome. We integrate RNA sequencing (RNA-seq) (to comprehensively report intron retention, differential transcript usage, and gene expression) with a ...[more]