Ontology highlight
ABSTRACT:
SUBMITTER: Park WJ
PROVIDER: S-EPMC4406097 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Park Woo-Jae WJ Park Joo-Won JW Merrill Alfred H AH Storch Judith J Pewzner-Jung Yael Y Futerman Anthony H AH
Biochimica et biophysica acta 20141201 12
Ceramide synthase 2 (CerS2) null mice cannot synthesize very-long acyl chain (C22-C24) ceramides resulting in significant alterations in the acyl chain composition of sphingolipids. We now demonstrate that hepatic triacylglycerol (TG) levels are reduced in the liver but not in the adipose tissue or skeletal muscle of the CerS2 null mouse, both before and after feeding with a high fat diet (HFD), where no weight gain was observed and large hepatic nodules appeared. Uptake of both BODIPY-palmitate ...[more]