Ontology highlight
ABSTRACT:
SUBMITTER: Sauc S
PROVIDER: S-EPMC4406124 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Saüc Sophie S Bulla Monica M Nunes Paula P Orci Lelio L Marchetti Anna A Antigny Fabrice F Bernheim Laurent L Cosson Pierre P Frieden Maud M Demaurex Nicolas N
Journal of cell science 20150303 8
STIM proteins populate and expand cortical endoplasmic reticulum (ER) sheets to mediate store-operated Ca(2+) entry (SOCE) by trapping and gating Orai channels in ER-plasma membrane clusters. A longer splice variant, STIM1L, forms permanent ER-plasma membrane clusters and mediates rapid Ca(2+) influx in muscle. Here, we used electron microscopy, total internal reflection fluorescence (TIRF) microscopy and Ca(2+) imaging to establish the trafficking and signaling properties of the two STIM1 isofo ...[more]