Ontology highlight
ABSTRACT:
SUBMITTER: Lin F
PROVIDER: S-EPMC4406300 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Lin Fang F Ghislat Ghita G Luo Shouqing S Renna Maurizio M Siddiqi Farah F Rubinsztein David C DC
Human molecular genetics 20150210 10
Perturbations in autophagy and apoptosis are associated with cancer development. XIAP and cIAP1 are two members of the inhibitors of apoptosis protein family whose expression is elevated in different cancers. Here we report that XIAP and cIAP1 induce autophagy by upregulating the transcription of Beclin 1, an essential autophagy gene. The E3 ubiquitin ligase activity of both proteins activates NFκB signalling, leading to the direct binding of p65 to the promoter of Beclin 1 and to its transcript ...[more]