Ontology highlight
ABSTRACT:
SUBMITTER: Anyaegbu EI
PROVIDER: S-EPMC4406792 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Anyaegbu Elizabeth I EI Shaw Andrey S AS Hruska Keith A KA Jain Sanjay S
Pediatric nephrology (Berlin, Germany) 20141223 6
<h4>Background</h4>Two coding variants--G1 and G2--in the apolipoprotein L-1 (APOL1) gene are associated with increased incidence of end-stage renal disease (ESRD) in the adult African American population. These variants associate with hypertension-attributed renal disease, focal segmental glomerulosclerosis (FSGS), and HIV-associated nephropathy. We hypothesized that as a genetic disease, APOL1 nephropathy has a pediatric phenotype.<h4>Methods</h4>We investigated the incidence of APOL1 variants ...[more]