Dataset Information

End Stage Renal Disease Predicts Increased Risk of Death in First Degree Relatives in the Norwegian Population.

ABSTRACT:

Background

Increased risk of end stage renal disease (ESRD) and death in Norwegian living kidney donors has been reported, most of the donors were related to the recipient. The present study investigates risk of death in first degree relatives of ESRD patients.

Methods

The Norwegian Population Registry, The Norwegian Cause of Death Registry and the Norwegian Renal Registry were linked. All citizens born in Norway, alive in 1960 and with at least one registered first degree relative were included; individuals who died during the first year of life were excluded. A cohort-design was used, ESRD in a first degree relative was the main exposure variable and death and causes of death were the main outcome variables. Cox regression statistics were used to investigate mortality risks.

Results

5 130 600 individuals were included, 27 508 had at least one first degree relative with ESRD. 828 022 died during follow-up, of whom 4105 had a first degree relative with ESRD. Adjusted hazard ratio (aHR) for death was 1.13 (1.09-1.16) in individuals with a relative with ESRD compared to those without a relative with ESRD. Excluding known hereditary renal disease, aHR decreased to 1.12 (1.09-1.15). Cardiovascular death aHR was 1.15 (1.10-1.21), of which cerebrovascular death 1.34 (1.22-1.50). aHR for death due to non-hereditary renal/ureteric disease was 2.29 (1.81-2.91) with renal failure 1.80 (1.26-2.56) and glomerular disease 5.69 (3.88-8.34) as main contributors. Diabetes mellitus death aHR was 1.68 (1.35-2.10). Absolute mortality risks increased most for the oldest cohorts with excess mortality of 148 per 100.000 person years for the cohort born 1920-39 and 218 for the cohort born 1900-1919.

Conclusions

ESRD in first degree relatives was associated with increased hazard ratio for death. Death due to cardiovascular disease, renal disease and diabetes mellitus increased the most.

SUBMITTER: Skrunes R

PROVIDER: S-EPMC5102372 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

End Stage Renal Disease Predicts Increased Risk of Death in First Degree Relatives in the Norwegian Population.

Skrunes Rannveig R Svarstad Einar E Reisæter Anna Varberg AV Marti Hans-Peter HP Vikse Bjørn Egil BE

PloS one 20161109 11

<h4>Background</h4>Increased risk of end stage renal disease (ESRD) and death in Norwegian living kidney donors has been reported, most of the donors were related to the recipient. The present study investigates risk of death in first degree relatives of ESRD patients.<h4>Methods</h4>The Norwegian Population Registry, The Norwegian Cause of Death Registry and the Norwegian Renal Registry were linked. All citizens born in Norway, alive in 1960 and with at least one registered first degree relativ ...[more]

PMID: 27828975

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Project description:ContextStudying sensorimotor and neurocognitive impairments in unaffected family members of individuals with autism may help identify familial pathophysiological mechanisms associated with the disorder.ObjectiveTo determine whether atypical sensorimotor or neurocognitive characteristics associated with autism are present in first-degree relatives of individuals with autism.DesignCase-control comparison of neurobehavioral functions.SettingUniversity medical center.ParticipantsFifty-seven first-degree relatives of individuals with autism and 40 age-, sex-, and IQ-matched healthy control participants (aged 8-54 years).Main outcome measuresOculomotor tests of sensorimotor responses (saccades and smooth pursuit); procedural learning and response inhibition; neuropsychological tests of motor, memory, and executive functions; and psychological measures of social behavior, communication skills, and obsessive-compulsive behaviors.ResultsOn eye movement testing, family members demonstrated saccadic hypometria, reduced steady-state pursuit gain, and a higher rate of voluntary response inhibition errors relative to controls. They also showed lateralized deficits in procedural learning and open-loop pursuit gain (initial 100 milliseconds of pursuit) and increased variability in the accuracy of large-amplitude saccades that were confined to rightward movements. In neuropsychological studies, only executive functions were impaired relative to those of controls. Family members reported more communication abnormalities and obsessive-compulsive behaviors than controls. Deficits across oculomotor, neuropsychological, and psychological domains were relatively independent from one another.ConclusionsFamily members of individuals with autism demonstrate oculomotor abnormalities implicating pontocerebellar and frontostriatal circuits and left-lateralized alterations of frontotemporal circuitry and striatum. The left-lateralized alterations have not been identified in other neuropsychiatric disorders and are of interest given atypical brain lateralization and language development associated with the disorder. Similar oculomotor deficits have been reported in individuals with autism, suggesting that they may be familial and useful for studies of neurophysiological and genetic mechanisms in autism.

Dataset Information

End Stage Renal Disease Predicts Increased Risk of Death in First Degree Relatives in the Norwegian Population.

Background

Methods

Results

Conclusions

Publications

End Stage Renal Disease Predicts Increased Risk of Death in First Degree Relatives in the Norwegian Population.

Similar Datasets

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