Acid-responsive nanospheres from an asparagine-derived amphiphile.
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ABSTRACT:
SUBMITTER: Mfuh AM
PROVIDER: S-EPMC4407701 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Acid-responsive nanospheres from an asparagine-derived amphiphile.
Mfuh Adelphe M AM Mahindaratne Mathew P D MP Yñigez-Gutierrez Audrey E AE Ramos Dominguez Juan R JR Bedell Jefferson T JT Garcia Carlos D CD Negrete George R GR
RSC advances 20150101
We describe the synthesis and self-assembly of an asparagine-derived amphiphile. The self-assembled systems formulated with the inclusion of cholesterol (0-50 mol%) show encapsulation for a hydrophobic model drug and rapidly disintegrate in response to mild acidic conditions. ...[more]
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