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Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery.

ABSTRACT: Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40°C to 60°C.

SUBMITTER: He S

PROVIDER: S-EPMC5464001 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery.

He Shawn S Tourkakis George G Berezin Oleg O Gerasimchuk Nikolay N Zhang Hairong H Zhou Haying H Izraely Asaf A Akers Walter J WJ Berezin Mikhail Y MY

Journal of materials chemistry. C 20160219 14

Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, ...[more]

PMID: 28603621

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