Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery.
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ABSTRACT:
SUBMITTER: He S
PROVIDER: S-EPMC5464001 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery.
He Shawn S Tourkakis George G Berezin Oleg O Gerasimchuk Nikolay N Zhang Hairong H Zhou Haying H Izraely Asaf A Akers Walter J WJ Berezin Mikhail Y MY
Journal of materials chemistry. C 20160219 14
Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, ...[more]
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