Associations among endocrine, inflammatory, and bone markers, body composition and weight loss induced bone loss.

ABSTRACT:

Introduction

Weight loss reduces co-morbidities of obesity, but decreases bone mass.

Purpose

Our aims were to (1) determine if adequate dairy intake attenuates weight loss-induced bone loss; (2) evaluate the associations of endocrine, inflammatory and bone markers, anthropometric and other parameters to bone mineral density and content (BMD, BMC) pre- and post-weight loss; and (3) model the contribution of these variables to post weight-loss BMD and BMC.

Methods

Overweight/obese women (BMI: 28-37 kg/m2) were enrolled in an energy reduced (-500 kcal/d; -2092 kJ/d) diet with adequate dairy (AD: 3-4 servings/d; n=25, 32.2±8.8 years) or low dairy (LD: ≤1 serving/d; n=26, 31.7±8.4 years). BMD, BMC and body composition were measured by DXA. Bone markers (CTX, PYD, BAP, OC),

SUBMITTER: Labouesse MA 

PROVIDER: S-EPMC4408214 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature