Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC4408780 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Liu Xinjian X He Yujun Y Li Fang F Huang Qian Q Kato Takamitsu A TA Hall Russell P RP Li Chuan-Yuan CY
Molecular cell 20150409 2
Apoptosis is typically considered an anti-oncogenic process since caspase activation can promote the elimination of genetically unstable or damaged cells. We report that a central effector of apoptosis, caspase-3, facilitates rather than suppresses chemical- and radiation-induced genetic instability and carcinogenesis. We found that a significant fraction of mammalian cells treated with ionizing radiation can survive despite caspase-3 activation. Moreover, this sublethal activation of caspase-3 ...[more]