Ontology highlight
ABSTRACT:
SUBMITTER: Wolf AS
PROVIDER: S-EPMC4408800 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Wolf Andrew S AS Grayhack Elizabeth J EJ
RNA (New York, N.Y.) 20150319 5
Quality control systems monitor and stop translation at some ribosomal stalls, but it is unknown if halting translation at such stalls actually prevents synthesis of abnormal polypeptides. In yeast, ribosome stalling occurs at Arg CGA codon repeats, with even two consecutive CGA codons able to reduce translation by up to 50%. The conserved eukaryotic Asc1 protein limits translation through internal Arg CGA codon repeats. We show that, in the absence of Asc1 protein, ribosomes continue translatin ...[more]