Ontology highlight
ABSTRACT:
SUBMITTER: Dassanayaka S
PROVIDER: S-EPMC4408906 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Dassanayaka Sujith S Readnower Ryan D RD Salabei Joshua K JK Long Bethany W BW Aird Allison L AL Zheng Yu-Ting YT Muthusamy Senthilkumar S Facundo Heberty T HT Hill Bradford G BG Jones Steven P SP
The Biochemical journal 20150401 1
Diabetes is characterized by hyperglycaemia and perturbations in intermediary metabolism. In particular, diabetes can augment flux through accessory pathways of glucose metabolism, such as the hexosamine biosynthetic pathway (HBP), which produces the sugar donor for the β-O-linked-N-acetylglucosamine (O-GlcNAc) post-translational modification of proteins. Diabetes also promotes mitochondrial dysfunction. Nevertheless, the relationships among diabetes, hyperglycaemia, mitochondrial dysfunction an ...[more]