Ontology highlight
ABSTRACT:
SUBMITTER: Isberg V
PROVIDER: S-EPMC4408928 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Isberg Vignir V de Graaf Chris C Bortolato Andrea A Cherezov Vadim V Katritch Vsevolod V Marshall Fiona H FH Mordalski Stefan S Pin Jean-Philippe JP Stevens Raymond C RC Vriend Gerrit G Gloriam David E DE
Trends in pharmacological sciences 20141222 1
Generic residue numbers facilitate comparisons of, for example, mutational effects, ligand interactions, and structural motifs. The numbering scheme by Ballesteros and Weinstein for residues within the class A GPCRs (G protein-coupled receptors) has more than 1100 citations, and the recent crystal structures for classes B, C, and F now call for a community consensus in residue numbering within and across these classes. Furthermore, the structural era has uncovered helix bulges and constrictions ...[more]