Ontology highlight
ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC4409868 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Huang Jing J Brown Andrew F AF Wu Jian J Xue Jing J Bley Christopher J CJ Rand Dustin P DP Wu Lijie L Zhang Rongguang R Chen Julian J-L JJ Lei Ming M
Nature structural & molecular biology 20140504 6
Telomerase is a large ribonucleoprotein complex minimally composed of a catalytic telomerase reverse transcriptase (TERT) and an RNA component (TR) that provides the template for telomeric DNA synthesis. However, it remains unclear how TERT and TR assemble into a functional telomerase. Here we report the crystal structure of the conserved regions 4 and 5 (CR4/5) of TR in complex with the TR-binding domain (TRBD) of TERT from the teleost fish Oryzias latipes. The structure shows that CR4/5 adopts ...[more]