Ontology highlight
ABSTRACT:
SUBMITTER: Aarntzen EH
PROVIDER: S-EPMC3215004 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Aarntzen Erik H J G EH Srinivas Mangala M De Wilt Johannes H W JH Jacobs Joannes F M JF Lesterhuis W Joost WJ Windhorst Albert D AD Troost Esther G EG Bonenkamp Johannes J JJ van Rossum Michelle M MM Blokx Willeke A M WA Mus Roel D RD Boerman Otto C OC Punt Cornelis J A CJ Figdor Carl G CG Oyen Wim J G WJ de Vries I Jolanda M IJ
Proceedings of the National Academy of Sciences of the United States of America 20111024 45
Current biomarkers are unable to adequately predict vaccine-induced immune protection in humans with infectious disease or cancer. However, timely and adequate assessment of antigen-specific immune responses is critical for successful vaccine development. Therefore, we have developed a method for the direct assessment of immune responses in vivo in a clinical setting. Melanoma patients with lymph node (LN) metastases received dendritic cell (DC) vaccine therapy, injected intranodally, followed b ...[more]