Ontology highlight
ABSTRACT:
SUBMITTER: Choi L
PROVIDER: S-EPMC4411215 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Choi L L Vernon J J Kopach O O Minett M S MS Mills K K Clayton P T PT Meert T T Wood J N JN
Neuroscience letters 20150216
Fabry disease is an X-linked lysosomal storage disorder characterised by accumulation of glycosphingolipids, and accompanied by clinical manifestations, such as cardiac disorders, renal failure, pain and peripheral neuropathy. Globotriaosylsphingosine (lyso-Gb3), a deacylated form of globotriaosylceramide (Gb3), has emerged as a marker of Fabry disease. We investigated the link between Gb3, lyso-Gb3 and pain. Plantar administration of lyso-Gb3 or Gb3 caused mechanical allodynia in healthy mice. ...[more]